Gluten remains a hot topic, and more owners today are searching for gluten free dog food for their pets, too.
Studies show that majority of dogs are actually not sensitive to gluten, but some definitely are.
A growing body of research demonstrated that gluten sensitivity itself is in fact real, and specific diets can help deal with its damaging effects.
Food allergies account for about 10% of all allergies in canines, and this includes sensitivity to gluten.
Table of Contents
- 1 What is Gluten?
- 2 Why is Gluten Bad for Dogs and People?
- 3 Gluten Sensitivity in Dogs
- 4 Is Gluten Free Dog Food Essential?
- 5 When is Gluten Free Dog Food Beneficial?
- 6 How to Know if a Dog Has Gluten Sensitivity?
- 7 Why is There Gluten in Dog Food?
- 8 Gluten Free Foods for a Homemade Diet
- 9 Take Home Message
Over 30% of Americans have eliminated gluten from their diets, and this trend continues into the pet food market with gluten free dog food becoming very popular but costly.
This article will examine how real gluten sensitivity in dogs is, what are the causes and treatments, and whether gluten free dog food can be the answer.
What is Gluten?
Gluten has a glue-like consistency that helps to form dog kibble. It’s achieved through mixing flour with water .
There are grains which do not contain gluten. These include rice, corn, oats, millet and quinoa.
It is important to bear in mind that a gluten free canine diet may not be grain free, but a grain free diet will always be gluten free.
Surveys show that over a third of Americans are trying to eliminate gluten from their diet, and many owners attempt to do the same with their pet foods.
Bottom Line: Gluten is a mix of two proteins and is mostly found in grains such as wheat, rye and barley. Gliadin in gluten is responsible for most of the damaging effects.
Why is Gluten Bad for Dogs and People?
Gluten isn’t necessarily all-bad. But before we can analyze why gluten may be harmful to dogs, we need to take a look at where this gluten free trend comes from, and that’s human diet.
The truth is that majority of pets and people, including many of those currently on a gluten free diet, can actually tolerate gluten just fine.
However, several reports have found many diseases related to either gluten or wheat .
In most cases, specific health conditions will result in side effects from consuming gluten.
For people, the three most common conditions where gluten should be avoided are:
- Celiac disease
- Gluten sensitivity
- Irritable Bowel Syndrome (IBS)
Note that the same breakdown cannot be replicated with dogs, and we’ll discuss this below.
Celiac disease is by far the most well-known reason to avoid gluten .
However, it’s rare in pets. In fact, there’s no record of dogs ever developing celiac disease.
Non-celiac gluten sensitivity, which has also been observed in dogs in different forms, remains undefined and may not even be real in humans where the symptoms are caused by something other than gluten.
But a major study found that out of 400 patients experiencing “gluten sensitivity,” only 55 people actually had problems with consuming gluten .
This remains by far the most applicable gluten related issue for dogs and other pets.
Irritable Bowel Disease (IBD) found in dogs has been shown to be different to human IBS .
Research on gluten sensitivity in dogs is still in its infancy, and these reports from human trials can help us better understand what may be the cause of adverse effects from gluten in canines.
Bottom Line: Gluten sensitivity in dogs is different to that in people. However, current studies on gluten consumption in human population may further explain how and why dogs are sensitive to gluten.
Gluten Sensitivity in Dogs
Gluten is digested in the dog’s small intestine by pancreatic enzymes. When a dog suffers from gluten sensitivity, the presence of gluten in the diet causes an inflammatory response in the intestine.
Canine’s intestine inflammation has several consequences, including:
- The atrophy (wasting) of the villi (small projections) in the lining of the small intestine responsible for helping dog’s body to absorb nutrients from food.
- An increase in the numbers of lymphocytes (a type of white blood cell), which are present in the dog’s intestine wall .
This damage to the intestine can make it harder for nutrients to be absorbed, eventually leading to malnutrition and weight loss in canines.
More unpleasant gastrointestinal symptoms may also occur, such as diarrhea and vomiting. Other signs like skin conditions are possible, depending on the severity of the allergy .
In other types of gluten sensitivity in dogs, this process can cause the body to produce anti-gliadin and anti-transglutaminase antibodies. They then enter the circulation, and react and launch an autoimmune attack in the dog’s body.
This is important as these antibodies can attack parts of the canine’s nervous system, causing neurological signs such as ataxia, paroxysmal movement disorders (abnormal movements during an episode) and even epilepsy.
In recent years, science has made progress on the mechanisms of gluten sensitivity both in humans and pets, but it is still not entirely understood.
We also need to look at correlation between FODMAPs and dogs with gluten sensitivity .
Some people with gluten issues were actually sensitive to FODMAPs and not gluten, which ultimately presents an interesting case to study in pets as well .
Bottom Line: Gluten intolerance in dogs is genetic. Presence of gluten in a diet of gluten sensitive dogs can have many detrimental health effects. Other wheat-related causes of food allergies in dogs are also possible.
Is Gluten Free Dog Food Essential?
Gluten is not necessarily bad for all dogs, thus a gluten free dog food diet isn’t always essential.
The grains that contain gluten can be a perfectly good source of carbohydrate, protein, fiber, trace minerals as well as vitamins B and E when forming part of a balanced canine diet .
Evidence is clear that gluten free dog food can definitely help dogs with gluten sensitivity.
Most Dogs Aren’t Sensitive to Gluten
A recent rise in perceived food intolerance in humans and the fashion for people to stick to gluten free diets has seen an increasing number of owners wanting to follow these trends with their dogs as well [43, 44, 45].
Despite the popularity, there is no scientific evidence to support that a gluten free dog diet is absolutely necessary to the general healthy canine population.
Therefore, majority of owners don’t have to worry about purchasing gluten free dog foods. However, there are cases (discussed below) where going gluten-free is required for a dog, and other reasons where this can simply be a better choice.
On a separate note, a school of thought also exist with the beliefs based around what dogs would eat in the wild, and gluten sensitivity is often part of that debate.
The major argument there is that since dogs would not have consumed grains in the wild, then grains should not be fed as part of their commercial diet.
Bottom Line: A gluten free diet can significantly improve health of dogs that are sensitive to gluten or wheat-related foods. Gluten free diet is not necessary for healthy dogs that can tolerate gluten, but may be beneficial for other reasons.
When is Gluten Free Dog Food Beneficial?
Unfortunately, food allergies in dogs, such as gluten sensitivity, cannot be prevented .
The equivalent to celiac disease in dogs is rare. However, there are some specific cases where it may be beneficial for dogs to avoid gluten, and feed a gluten free dog food.
Gluten free dog food can be beneficial for:
- Breeds with known sensitivities
- Dogs with allergies to gluten
- Dogs with epilepsy
Let’s take a closer look at all three of these cases.
Breeds with Known Sensitivities
There are certain dog breeds that have genetic predisposition to gluten sensitivity.
In some cases this seems to be age-related, and as they reach adult hood they are no longer affected [53, 54]. The reason for this is currently unknown.
Although the condition is genetic, it is not related to the same genes as in human celiac disease .
Soft Coated Wheaten Terriers: It appears that SCWTs are also genetically sensitive to gluten or gluten-related compounds.
PLE is a condition where the intestine becomes damaged and a large amount of protein leaks out and is lost.
PLN is a condition with a similar concept as PLE but protein is lost into the urine instead.
The cause is currently unknown but these dogs were found to have a type of gluten sensitivity which may be responsible for affecting canine’s nervous system .
In the above three breeds, a properly balanced gluten free dog food diet is probably a good choice right from the start of adoption or birth.
Dogs with Allergies to Gluten
As we have already concluded, it is definitely possible for dogs to be allergic to gluten.
However, the most frequently identified dietary allergens in dogs are not grains but rather of meat origin, specifically beef, and therefore are not gluten related [61, 48].
Once you establish that a dog definitely suffers from gluten (more on how to do that below), then it’s time to completely switch to a gluten free dog food diet.
The most common signs associated with dietary and gluten related allergies in dogs are often skin related .
Symptoms of canine gluten allergy to watch out for include:
- Excessive hair loss
- Bald patches
- Inflamed skin
- Sores and scabs
- “Hot spots” (red, irritated, itchy areas)
Remember that these signs are also common to many other types of allergies in dogs.
When your dog is suffering from any of the above, it does not necessarily mean that gluten is causing it. It’s necessary to consult with a veterinarian to find what is the actual reason.
Dogs with Epilepsy
Antibodies produced in response to gluten may act as a trigger to seizures in dogs.
But further research is needed as the design of these studies may provide false positives .
Bottom Line: Studies show that a gluten free dog food diet can help pets with allergies to gluten, epileptic dogs and breeds that are genetically predisposed to gluten sensitivity.
How to Know if a Dog Has Gluten Sensitivity?
Diagnosing gluten sensitivity in dogs is possible, but it takes time to be completely certain.
When it comes to dog food allergies, there are two options: blood tests and food trials.
How to Use Elimination Diet?
Dog elimination diets normally last from 6 to 12 weeks and must be very strict.
Your vet and nutritionist can help to identify an appropriate dietary regime and the right gluten free dog food that does not contain any allergens.
This will need to be trialed over a period of time to see if dog’s allergy symptoms improve.
For the period of trial feeding, your pets absolutely cannot eat any dog treats, rawhide, pig ears or flavored medications; only specific foods.
Studies have shown that commercial grain free and gluten free dog food brands can help with a more accurate assessment in the elimination diet challenge since most people can’t do homemade dog food right .
Bottom Line: Elimination diet is the only way to find out whether a dog is sensitive to gluten. These diets last 6-12 weeks and must be very strict.
Why is There Gluten in Dog Food?
Apart from contributing towards the nutritional make-up of a dog food, gluten acts as a binding agent. It binds everything in a dry dog food together so that it can be easily made into kibble.
Although ingredients that contain gluten are not a problem in principal, gluten should not be used as a substitute for other good quality protein sources.
Reading lists of ingredients on dog food labels can help identify if gluten has been used to increase the levels of protein in its make up.
Some manufacturers use gluten as a cheap substitute for animal protein, and those dog food brands need to be avoided for more than this reason alone.
Higher Quality Ingredients in Gluten Free Dog Food
One perceived advantage to feeding a grain free or gluten free dog food diet is the quality of ingredients in these foods.
This also may be true for sources of protein used in dog foods since they are likely to be of better quality and clearly identified.
Overall, grain free dog foods are also likely to contain higher levels of protein.
This isn’t surprising, since adding gluten in dog foods – even if it’s not at all harmful to most canines – is a cheaper way to manufacture canine feed [76, 77, 78].
A gluten free diet could range from a homemade dog diet formulated by a veterinary nutritionist to one of the many commercial gluten free dog food brands currently available.
A few brands that manufacture gluten free dog foods are:
- Taste of the Wild Grain Free Formula (A rating)
- Castor & Pollux Organix Grain Free Formula (A rating)
- The Honest Kitchen Grain Free Formula
- Nutro Ultra Gluten Free Formula
- Artemis Grain Free Formula (A rating)
Making a nutritionally well-balanced homemade dog food is a tricky business as is, but ensuring it’s also gluten free adds yet another step to complicate things even further. But it’s doable.
Bottom Line: Sustainability in the pet food industry matters. Gluten isn’t harmful to most dogs, and it acts as a binding agent in kibble. Gluten free dog food may have higher quality ingredients and higher levels of protein.
Gluten Free Foods for a Homemade Diet
If you choose to avoid commercial gluten free dog foods and opt for making your own homemade gluten free dog food, there are a few things you need to be aware of.
First of all, reading labels of every food you buy for your dog is key.
Always choose naturally gluten free foods instead of processed foods with a “gluten free” label.
Foods to avoid
Here’s a list of most common foods with gluten your dog needs to avoid:
- Processed foods
- Baked goods
- Wheat (all forms)
A lot of these foods shouldn’t be in your pet’s diet in the first place, but it’s particularly important to avoid them for dogs with gluten sensitivity.
Certain foods can be processed in the same facility as gluten . Always read labels.
Natural foods to include
Here’s a list of foods that are gluten free which you can use in homemade dog food:
- Oats (gluten free)
- Oils and fats
Remember that dogs can’t eat some of the fruits, vegetables, nuts, oils or grains in the category, so pick only those that are healthy and can be tolerated by a canine’s body.
Dogs on a homemade diet may also need certain supplements for complete balance.
Bottom Line: There are plenty of natural foods that are gluten free which can be used in homemade dog food diet. Reading labels and adding supplements for a complete nutritional balance is important.
Take Home Message
Gluten is a family of proteins, and acts as a binding agent to form kibble.
Most dogs won’t have any side effects from gluten when it’s part of a nutritionally balanced diet.
A very small percentage of dogs and some breeds in particular are affected by gluten sensitivities. In this group of dogs, a gluten free dog food diet can be extremely beneficial.
The best way to know if a dog has gluten sensitivity is through elimination diet.
Studies have also shown that gluten free dog food diet may benefit canines with epilepsy.
Even though there’s no reason to buy gluten free dog food for healthy pets, it’s possible that this type of dog food may have higher levels of protein and better quality ingredients.[toggle title=”References“]
- Wieser H. Relation between gliadin structure and coeliac toxicity. Acta Paediatr Suppl. 1996 May;412:3-9.
- Wieser H. Chemistry of gluten proteins. Food Microbiol. 2007 Apr;24(2):115-9. Epub 2006 Sep 7.
- Tilley KA1, Benjamin RE, Bagorogoza KE, Okot-Kotber BM, Prakash O, Kwen H. Tyrosine cross-links: molecular basis of gluten structure and function. J Agric Food Chem. 2001 May;49(5):2627-32.
- Sapone A1, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, Kaukinen K, Rostami K, Sanders DS, Schumann M, Ullrich R, Villalta D, Volta U, Catassi C, Fasano A. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 2012 Feb 7;10:13. doi: 10.1186/1741-7015-10-13.
- Rubio-Tapia A1, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE. The prevalence of celiac disease in the United States. Am J Gastroenterol. 2012 Oct;107(10):1538-44; quiz 1537, 1545. doi: 10.1038/ajg.2012.219. Epub 2012 Jul 31.
- Castillo NE1, Theethira TG1, Leffler DA2. The present and the future in the diagnosis and management of celiac disease. Gastroenterol Rep (Oxf). 2015 Feb;3(1):3-11. doi: 10.1093/gastro/gou065. Epub 2014 Oct 17.
- Rubio-Tapia A1, Hill ID, Kelly CP, Calderwood AH, Murray JA; American College of Gastroenterology. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol. 2013 May;108(5):656-76; quiz 677. doi: 10.1038/ajg.2013.79. Epub 2013 Apr 23.
- Nadhem ON1, Azeez G, Smalligan RD, Urban S. Review and practice guidelines for celiac disease in 2014. Postgrad Med. 2015 Apr;127(3):259-65. doi: 10.1080/00325481.2015.1015926. Epub 2015 Feb 23.
- Corrao G1, Corazza GR, Bagnardi V, Brusco G, Ciacci C, Cottone M, Sategna Guidetti C, Usai P, Cesari P, Pelli MA, Loperfido S, Volta U, Calabró A, Certo M; Club del Tenue Study Group. Mortality in patients with coeliac disease and their relatives: a cohort study. Lancet. 2001 Aug 4;358(9279):356-61.
- van Heel DA1, West J. Recent advances in coeliac disease. Gut. 2006 Jul;55(7):1037-46.
- Gujral N1, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012 Nov 14;18(42):6036-59. doi: 10.3748/wjg.v18.i42.6036.
- Fasano A1, Sapone A2, Zevallos V3, Schuppan D4. Nonceliac gluten sensitivity. Gastroenterology. 2015 May;148(6):1195-204. doi: 10.1053/j.gastro.2014.12.049. Epub 2015 Jan 9.
- Molina-Infante J1, Santolaria S, Sanders DS, Fernández-Bañares F. Systematic review: noncoeliac gluten sensitivity. Aliment Pharmacol Ther. 2015 May;41(9):807-20. doi: 10.1111/apt.13155. Epub 2015 Mar 6.
- Mansueto P1, Seidita A, D’Alcamo A, Carroccio A. Non-celiac gluten sensitivity: literature review. J Am Coll Nutr. 2014;33(1):39-54. doi: 10.1080/07315724.2014.869996.
- Czaja-Bulsa G1. Non coeliac gluten sensitivity – A new disease with gluten intolerance. Clin Nutr. 2015 Apr;34(2):189-94. doi: 10.1016/j.clnu.2014.08.012. Epub 2014 Aug 29.
- Hadjivassiliou M1, Sanders DS, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D. Gluten sensitivity: from gut to brain. Lancet Neurol. 2010 Mar;9(3):318-30. doi: 10.1016/S1474-4422(09)70290-X.
- Capannolo A1, Viscido A, Barkad MA, Valerii G, Ciccone F, Melideo D, Frieri G, Latella G. Non-Celiac Gluten Sensitivity among Patients Perceiving Gluten-Related Symptoms. Digestion. 2015;92(1):8-13. doi: 10.1159/000430090. Epub 2015 May 30.
- Zuidmeer L1, Goldhahn K, Rona RJ, Gislason D, Madsen C, Summers C, Sodergren E, Dahlstrom J, Lindner T, Sigurdardottir ST, McBride D, Keil T. The prevalence of plant food allergies: a systematic review. J Allergy Clin Immunol. 2008 May;121(5):1210-1218.e4. doi: 10.1016/j.jaci.2008.02.019. Epub 2008 Apr 18.
- Shanti Eswaran, MD, Akash Goel, MD, William D. Chey, MD. What Role Does Wheat Play in the Symptoms of Irritable Bowel Syndrome? Gastroenterol Hepatol (N Y). 2013 Feb; 9(2): 85–91.
- Makharia A1, Catassi C2, Makharia GK1. The Overlap between Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity: A Clinical Dilemma. Nutrients. 2015 Dec 10;7(12):10417-26. doi: 10.3390/nu7125541.
- Biesiekierski JR1, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD, Shepherd SJ, Muir JG, Gibson PR. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol. 2011 Mar;106(3):508-14; quiz 515. doi: 10.1038/ajg.2010.487. Epub 2011 Jan 11.
- Vazquez-Roque MI1, Camilleri M, Smyrk T, Murray JA, Marietta E, O’Neill J, Carlson P, Lamsam J, Janzow D, Eckert D, Burton D, Zinsmeister AR. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology. 2013 May;144(5):903-911.e3. doi: 10.1053/j.gastro.2013.01.049. Epub 2013 Jan 25.
- Aziz I1, Trott N2, Briggs R2, North JR2, Hadjivassiliou M2, Sanders DS2. Efficacy of a Gluten-Free Diet in Subjects With Irritable Bowel Syndrome-Diarrhea Unaware of Their HLA-DQ2/8 Genotype. Clin Gastroenterol Hepatol. 2015 Dec 31. pii: S1542-3565(15)01715-2. doi: 10.1016/j.cgh.2015.12.031. [Epub ahead of print]
- Matteo Cerquetella, Andrea Spaterna, Fulvio Laus, Beniamino Tesei, Giacomo Rossi, Elisabetta Antonelli, Vincenzo Villanacci, Gabrio Bassotti. Inflammatory bowel disease in the dog: Differences and similarities with humans. World J Gastroenterol. 2010 Mar 7; 16(9): 1050–1056. Published online 2010 Mar 7. doi: 10.3748/wjg.v16.i9.1050
- Jergens AE1, Simpson KW. Inflammatory bowel disease in veterinary medicine. Front Biosci (Elite Ed). 2012 Jan 1;4:1404-19.
- Malewska K1, Rychlik A, Nieradka R, Kander M. Treatment of inflammatory bowel disease (IBD) in dogs and cats. Pol J Vet Sci. 2011;14(1):165-71.
- Simpson JW1. Diet and large intestinal disease in dogs and cats. J Nutr. 1998 Dec;128(12 Suppl):2717S-2722S.
- Angelucci E1, Malesci A, Danese S. Budesonide: teaching an old dog new tricks for inflammatory bowel disease treatment. Curr Med Chem. 2008;15(24):2527-35.
- Eric V. Marietta, PhD, Joseph A. Murray, MD. Animal Models to Study Gluten Sensitivity. Semin Immunopathol. Author manuscript; available in PMC 2013 Jul 1. Published in final edited form as: Semin Immunopathol. 2012 Jul; 34(4): 497–511. Published online 2012 May 11. doi: 10.1007/s00281-012-0315-y.
- Batt RM, Carter MW, McLean L. Morphological and biochemical studies of a naturally occurring enteropathy in the Irish setter dog: a comparison with coeliac disease in man. Res Vet Sci. 1984 Nov;37(3):339-46.
- E J Hall, R M Batt. Dietary modulation of gluten sensitivity in a naturally occurring enteropathy of Irish setter dogs. Gut. 1992 Feb; 33(2): 198–205.
- Margaret A Maglione, MPP, Adeyemi Okunogbe, MBChB, Brett Ewing, MS, Sean Grant, PhD, Sydne J Newberry, PhD, Aneesa Motala, BA, Roberta Shanman, MLS, Nelly Mejia, MPhil, Aziza Arifkhanova, MS, Paul Shekelle, MD, PhD, and Gregory Harmon, MD. Diagnosis of Celiac Disease. Comparative Effectiveness Reviews, No. 162. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 Jan. Report No.: 15(16)-EHC032-EF.
- Rostom A, Dubé C, Cranney A, Saloojee N, Sy R, Garritty C, Sampson M, Zhang L, Yazdi F, Mamaladze V, Pan I, McNeil J, Moher D, Mack D, Patel D. Celiac disease. Evid Rep Technol Assess (Summ). 2004 Jun;(104):1-6.
- Ishida R1, Masuda K, Kurata K, Ohno K, Tsujimoto H. Lymphocyte blastogenic responses to inciting food allergens in dogs with food hypersensitivity. J Vet Intern Med. 2004 Jan-Feb;18(1):25-30.
- Paterson S1. Food hypersensitivity in 20 dogs with skin and gastrointestinal signs. J Small Anim Pract. 1995 Dec;36(12):529-34.
- Marcason W1. What is the FODMAP diet? J Acad Nutr Diet. 2012 Oct;112(10):1696. doi: 10.1016/j.jand.2012.08.005.
- Biesiekierski JR1, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology. 2013 Aug;145(2):320-8.e1-3. doi: 10.1053/j.gastro.2013.04.051. Epub 2013 May 4.
- Fardet A1. New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? Nutr Res Rev. 2010 Jun;23(1):65-134. doi: 10.1017/S0954422410000041. Epub 2010 Jun 22.
- Bethune MT1, Borda JT, Ribka E, Liu MX, Phillippi-Falkenstein K, Jandacek RJ, Doxiadis GG, Gray GM, Khosla C, Sestak K. A non-human primate model for gluten sensitivity. PLoS One. 2008 Feb 20;3(2):e1614. doi: 10.1371/journal.pone.0001614.
- Lowrie M1, Garden OA2, Hadjivassiliou M3, Harvey RJ4, Sanders DS5, Powell R6, Garosi L1. The Clinical and Serological Effect of a Gluten-Free Diet in Border Terriers with Epileptoid Cramping Syndrome. J Vet Intern Med. 2015 Nov-Dec;29(6):1564-8. doi: 10.1111/jvim.13643. Epub 2015 Oct 25.
- Pemberton PW1, Lobley RW, Holmes R, Sørensen SH, Batt RM. Gluten-sensitive enteropathy in Irish setter dogs: characterisation of jejunal microvillar membrane proteins by two-dimensional electrophoresis. Res Vet Sci. 1997 Mar-Apr;62(2):191-3.
- EV Marietta, CS David, JA Murray. Important Lessons Derived From Animal Models of Celiac Disease. Int Rev Immunol. Author manuscript; available in PMC 2012 Oct 24. Published in final edited form as: Int Rev Immunol. 2011 Aug; 30(4): 197–206. doi: 10.3109/08830185.2011.598978
- Knibb RC1, Armstrong A, Booth DA, Platts RG, Booth IW, MacDonald A. Psychological characteristics of people with perceived food intolerance in a community sample. J Psychosom Res. 1999 Dec;47(6):545-54.
- Young E1, Stoneham MD, Petruckevitch A, Barton J, Rona R. A population study of food intolerance. Lancet. 1994 May 7;343(8906):1127-30.
- Woods RK, Stoney RM, Raven J, et al. (2002) Reported food reactions overestimate true food allergy in the community. Eur J Clin Nutr 56:31-36
- Axelsson E1, Ratnakumar A, Arendt ML, Maqbool K, Webster MT, Perloski M, Liberg O, Arnemo JM, Hedhammar A, Lindblad-Toh K. The genomic signature of dog domestication reveals adaptation to a starch-rich diet. Nature. 2013 Mar 21;495(7441):360-4. doi: 10.1038/nature11837. Epub 2013 Jan 23.
- Ann Wortinger (2005) Nutritional Myths. Journal of the American Animal Hospital Association: July/August 2005, Vol. 41, No. 4, pp. 273-276.
- Kennis RA1. Food allergies: update of pathogenesis, diagnoses, and management. Vet Clin North Am Small Anim Pract. 2006 Jan;36(1):175-84, vii-viii.
- Hall EJ1, Batt RM. Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish setter dogs. Gut. 1991 Jul;32(7):749-53.
- Garden OA1, Pidduck H, Lakhani KH, Walker D, Wood JL, Batt RM. Inheritance of gluten-sensitive enteropathy in Irish Setters. Am J Vet Res. 2000 Apr;61(4):462-8.
- S C Daminet. Gluten-sensitive enteropathy in a family of Irish setters. Can Vet J. 1996 Dec; 37(12): 745–746.
- German AJ1, Hall EJ, Day MJ. Chronic intestinal inflammation and intestinal disease in dogs. J Vet Intern Med. 2003 Jan-Feb;17(1):8-20.
- Elwood CM, Moore PF, Batt RM. (2001) Expression of gluten sensitive enteropathy (GSE) of Irish Setter dogs may be age dependent. J Vet Intern Med;15:274.
- Batt RM, Carter MW, McLean L. Wheat-sensitive enteropathy in Irish setter dogs: possible age-related brush border abnormalities. Res Vet Sci. 1985 Jul;39(1):80-3.
- Polvi A1, Garden OA, Houlston RS, Maki M, Batt RM, Partanen J. Genetic susceptibility to gluten sensitive enteropathy in Irish setter dogs is not linked to the major histocompatibility complex. Tissue Antigens. 1998 Dec;52(6):543-9.
- Vaden SL1, Sellon RK, Melgarejo LT, Williams DA, Trogdon MM, VanCamp SD, Argenzio RA. Evaluation of intestinal permeability and gluten sensitivity in Soft-Coated Wheaten Terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both. Am J Vet Res. 2000 May;61(5):518-24.
- Littman, M. P., & Giger, U. (1990). Familial protein-losing enteropathy (PLE) and/or protein-losing nephropathy (PLN) in Soft-coated Wheaten Terriers (SCWT). In ACVIM Abstr (Vol. 1135).
- Vaden SL1, Hammerberg B, Davenport DJ, Orton SM, Trogdon MM, Melgarejo LT, VanCamp SD, Williams DA. Food hypersensitivity reactions in Soft Coated Wheaten Terriers with protein-losing enteropathy or protein-losing nephropathy or both: gastroscopic food sensitivity testing, dietary provocation, and fecal immunoglobulin E. J Vet Intern Med. 2000 Jan-Feb;14(1):60-7.
- Littman MP1, Dambach DM, Vaden SL, Giger U. Familial protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers: 222 cases (1983-1997). J Vet Intern Med. 2000 Jan-Feb;14(1):68-80.
- Black V1, Garosi L1, Lowrie M1, Harvey RJ2, Gale J3. Phenotypic characterisation of canine epileptoid cramping syndrome in the Border terrier. J Small Anim Pract. 2014 Feb;55(2):102-7. doi: 10.1111/jsap.12170. Epub 2013 Dec 26.
- Carlotti, D. N., Remy, I. and Prost, C. (1990), Food Allergy In Dogs And Cats. A Review and Report of 43 Cases. Veterinary Dermatology, 1: 55–62. doi: 10.1111/j.1365-3164.1990.tb00080.x
- Chesney CJ. Food sensitivity in the dog: a quantitative study. J Small Anim Pract. 2002 May;43(5):203-7.
- Newell GW, Erickson TC, et al. Effect of wheat gluten diet on the electroencephalograms of dogs. Proc Soc Exp Biol Med. 1947 May;65(1):115.
- V Black, L Garosi, M Lowrie, R J Harvey, J Gale. Phenotypic characterisation of canine epileptoid cramping syndrome in the Border terrier. J Small Anim Pract. 2014 Feb; 55(2): 102–107. doi: 10.1111/jsap.12170
- Muñana KR1, Zhang D, Patterson EE. Placebo effect in canine epilepsy trials. J Vet Intern Med. 2010 Jan-Feb;24(1):166-70. doi: 10.1111/j.1939-1676.2009.0407.x.
- Mavroudi A1, Karatza E, Papastavrou T, Panteliadis C, Spiroglou K. Successful treatment of epilepsy and celiac disease with a gluten-free diet. Pediatr Neurol. 2005 Oct;33(4):292-5.
- Hugh J Freeman. Neurological disorders in adult celiac disease. Can J Gastroenterol. 2008 Nov; 22(11): 909–911.
- Canales P1, Mery VP, Larrondo FJ, Bravo FL, Godoy J. Epilepsy and celiac disease: favorable outcome with a gluten-free diet in a patient refractory to antiepileptic drugs. Neurologist. 2006 Nov;12(6):318-21.
- Jackson HA1, Jackson MW, Coblentz L, Hammerberg B. Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy. Vet Dermatol. 2003 Aug;14(4):181-7.
- Zimmer A1, Bexley J, Halliwell RE, Mueller RS. Food allergen-specific serum IgG and IgE before and after elimination diets in allergic dogs. Vet Immunol Immunopathol. 2011 Dec 15;144(3-4):442-7. doi: 10.1016/j.vetimm.2011.09.001. Epub 2011 Sep 10.
- Jeffers JG1, Meyer EK, Sosis EJ. Responses of dogs with food allergies to single-ingredient dietary provocation. J Am Vet Med Assoc. 1996 Aug 1;209(3):608-11.
- Harvey, R. G. (1993), Food allergy and dietary intolerance in dogs: A report of 25 cases. Journal of Small Animal Practice, 34: 175–179. doi: 10.1111/j.1748-5827.1993.tb02647.x
- Tapp T1, Griffin C, Rosenkrantz W, Muse R, Boord M. Comparison of a commercial limited-antigen diet versus home-prepared diets in the diagnosis of canine adverse food reaction. Vet Ther. 2002 Fall;3(3):244-51.
- Bethlehem S1, Bexley J, Mueller RS. Patch testing and allergen-specific serum IgE and IgG antibodies in the diagnosis of canine adverse food reactions. Vet Immunol Immunopathol. 2012 Feb 15;145(3-4):582-9. doi: 10.1016/j.vetimm.2012.01.003. Epub 2012 Jan 12.
- Olivry T1, Deangelo KB, Dunston SM, Clarke KB, McCall CA. Patch testing of experimentally sensitized beagle dogs: development of a model for skin lesions of atopic dermatitis. Vet Dermatol. 2006 Apr;17(2):95-102.
- Kelly S. Swanson, Rebecca A. Carter, Tracy P. Yount, Jan Aretz, Preston R. Buff. Nutritional Sustainability of Pet Foods. Adv Nutr. 2013 Mar; 4(2): 141–150. Published online 2013 Mar 6. doi: 10.3945/an.112.003335
- Deng P, Swanson KS. COMPANION ANIMALS SYMPOSIUM: Future aspects and perceptions of companion animal nutrition and sustainability. J Anim Sci. 2015 Mar;93(3):823-34. doi: 10.2527/jas.2014-8520.
- Swanson KS1, Carter RA, Yount TP, Aretz J, Buff PR. Nutritional sustainability of pet foods. Adv Nutr. 2013 Mar 1;4(2):141-50. doi: 10.3945/an.112.003335.
- Stockman J1, Fascetti AJ, Kass PH, Larsen JA. Evaluation of recipes of home-prepared maintenance diets for dogs. J Am Vet Med Assoc. 2013 Jun 1;242(11):1500-5. doi: 10.2460/javma.242.11.1500.
- Larsen JA1, Parks EM, Heinze CR, Fascetti AJ. Evaluation of recipes for home-prepared diets for dogs and cats with chronic kidney disease. J Am Vet Med Assoc. 2012 Mar 1;240(5):532-8. doi: 10.2460/javma.240.5.532.
- Roudebush, P. and Cowell, C. S. (1992), Results of a Hypoallergenic Diet Survey of Veterinarians in North America with a Nutritional Evaluation of Homemade Diet Prescriptions. Veterinary Dermatology, 3: 23–28. doi: 10.1111/j.1365-3164.1992.tb00139.x
- Taylor MB1, Geiger DA, Saker KE, Larson MM. Diffuse osteopenia and myelopathy in a puppy fed a diet composed of an organic premix and raw ground beef. J Am Vet Med Assoc. 2009 Apr 15;234(8):1041-8. doi: 10.2460/javma.234.8.1041.
- Freeman LM1, Michel KE. Evaluation of raw food diets for dogs. J Am Vet Med Assoc. 2001 Mar 1;218(5):705-9.
- Heinze CR1, Gomez FC, Freeman LM. Assessment of commercial diets and recipes for home-prepared diets recommended for dogs with cancer. J Am Vet Med Assoc. 2012 Dec 1;241(11):1453-60. doi: 10.2460/javma.241.11.1453.
- Francavilla R, Cristofori F, Stella M, Borrelli G, Naspi G, Castellaneta S. Treatment of celiac disease: from gluten-free diet to novel therapies. Minerva Pediatr. 2014 Oct;66(5):501-16.
- de Sousa Moraes LF1, Grzeskowiak LM2, de Sales Teixeira TF2, Gouveia Peluzio Mdo C2. Intestinal microbiota and probiotics in celiac disease. Clin Microbiol Rev. 2014 Jul;27(3):482-9. doi: 10.1128/CMR.00106-13.
- K Lindfors, T Blomqvist, K Juuti-Uusitalo, S Stenman, J Venäläinen, M Mäki, K Kaukinen. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol. 2008 Jun; 152(3): 552–558. doi: 10.1111/j.1365-2249.2008.03635.x
- Lorenzo Pisarello MJ1, Vintiñi EO, González SN, Pagani F, Medina MS. Decrease in lactobacilli in the intestinal microbiota of celiac children with a gluten-free diet, and selection of potentially probiotic strains. Can J Microbiol. 2015 Jan;61(1):32-7. doi: 10.1139/cjm-2014-0472.
- Baillon ML1, Marshall-Jones ZV, Butterwick RF. Effects of probiotic Lactobacillus acidophilus strain DSM13241 in healthy adult dogs. Am J Vet Res. 2004 Mar;65(3):338-43.
- Grześkowiak Ł1, Endo A2, Beasley S3, Salminen S4. Microbiota and probiotics in canine and feline welfare. Anaerobe. 2015 Aug;34:14-23. doi: 10.1016/j.anaerobe.2015.04.002. Epub 2015 Apr 8.
- Kelley RL1, Minikhiem D, Kiely B, O’Mahony L, O’Sullivan D, Boileau T, Park JS. Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea. Vet Ther. 2009 Fall;10(3):121-30.