Nutramax Dasuquin with MSM for Dogs Review

Nutramax Dasuquin with MSM for Dogs Review

Dog supplement description: “Dasuquin combines NMX1000 ASU and decaffeinated tea with Cosequin’s FCHG49 glucosamine hydrochloride and TRH122 low molecular weight chondroitin sulfate to provide the most comprehensive joint health management formula available for dogs. Dasuquin is a dual synergistic formula: its specific glucosamine hydrochloride and low molecular weight chondroitin sulfate have demonstrated synergy in stimulating cartilage matrix production, while ASU also acts synergistically with glucosamine.”

[tabs][tab title =”Overview”]Dasuquin with MSM is a new breed of joint health supplement in a tasty chewable tablet for dogs that goes beyond standard glucosamine supplements. It contains avocado/soybean unsaponifiables, or ASU, fortified with green tea, combined with glucosamine hydrochloride, MSM and low molecular weight chondroitin sulfate. It is the most complete joint support supplement available. Dasuquin with MSM is a non-prescription (OTC) product available as flavored, chewable tablets.

Dasuquin with MSM is a comprehensive joint health supplement for dogs containing proprietary ingredients, which goes above and beyond standard glucosamine/chondroitin sulfate supplements.[/tab] [tab title =”Ingredients”]Dasuquin with MSM for Small to Medium Dogs (under 60 lbs): Glucosamine Hydrochloride (600mg), Methylsulfonomethane (MSM) (400mg), Sodium Chondroitin Sulfate (250mg), Avocado/Soybean Unsaponifiables (45mg). Also contains Microcrystalline cellulose, dextrose, natural flavor, dried brewers yeast, magnesium stearate, gum resin, soy protein isolate, soy lecithin, tea, silicon dioxide, natural and artificial flavor, and mixed tocopherols.

Dasuquin With MSM for Large Dogs (60 lbs and over): Glucosamine Hydrochloride (900mg), Methylsulfonomethane (MSM) (800mg), Sodium Chondroitin Sulfate (350mg), Avocado/Soybean Unsaponifiables (90mg). Also contains microcrystalline cellulose, natural flavor, dextrose, dried brewers yeast, magnesium stearate, gum resin, soy protein isolate, soy lecithin, tea, silicon dioxide, natural and artificial flavor, and mixed tocopherols.[/tab] [tab title =”Analysis”]Dasuquin contains avocado/soybean unsaponifiables (ASU), which have shown to help protect cartilage and improve joint function. The ASU also helps potentiate the activity of Glucosamine and chondroitin. The combination of all three ingredients supports cartilage production and blocks enzymes that break down cartilage in your pet’s body. Glucosamine is a natural compound that is found in healthy cartilage in both humans and pets. It helps hydrate healthy joints by increasing the production of molecules that bind and hold water in the cartilage. Healthy cartilage provides cushioning which helps protect a pet’s joints while exercising.

Further research on the effectiveness of glucosamine is still needed, but many of our customers find it to be very beneficial to their pets. Dasuquin with MSM for Dogs also contains methylsulfonylmethane (MSM), which has been shown to be helpful in relieving pain and inflammation.[/tab] [tab title=”Uses”]Dasuquin with MSM for Small to Medium Dogs for the initial 4 to 6 week administration period for dogs weighing less than 10 lbs give 1/2 chewable tablet daily. For dogs weighing 10 to 29 lbs give 1 chewable tablet daily and for dogs 30-59 lbs give 2 chewable tablets daily. The suggested maintenance level for dogs less than 10 lbs is 1/2 chewable tablet daily, for dogs 10 to 29 lbs give 1/2 chewable tablet daily and for dogs 30 to 59 lbs give 1 chewable tablet daily.

Dasuquin with MSM for Large Dogs (60-120 lbs) for the initial 4 to 6 week administration period give 2 chewable tablets daily. The suggested maintenance level is to give 1 chewable tablet daily.

Dasuquin with MSM chewable tablets can be given as a treat or crumbled and mixed with food.[/tab] [tab title =”Side Effects”]No side effects have been reported at the time of this writing; please see detailed breakdown below.[/tab] [tab title =”Manufactured”]Made in the USA (Maryland, South Carolina)

2208 Lakeside Boulevard
Edgewood, MD 21040
Toll free: 888-886-6442
Toll free: 800-925-5187
Local: 410-776-4000[/tab][/tabs]

Nutramax Dasuquin with MSM for Dogs

Nutramax Dasuquin with MSM for Dogs ReviewNutramax Dasuquin with MSM for dogs is a supplement given to canines to promote healthy joints and eliminate or lessen symptoms of arthritis in dogs. It contains glucosamine and chondroitin sulfate in a formulation that includes ASU and decaffeinated tea, and MSM (methylsulfonylmethane) for additional joint support.

Research and scientific evidence on the two primary ingredients of the Dasuquin supplement – glucosamine and chondroitin sulfate – supports their use for osteoarthritic pain. Additional components like ASU (avocado/soybean unsaponifiables) and MSM are there for additional support. If you have a dog experiencing joint pain, suffering from arthritis or cartilage wear, the science behind the Dasuquin supplement ingredients says that it can definitely provide reduction of pain for your dog.

What you need to know about this supplement

Nutramax Dasuquin with MSM for dogs supplement should only be given to a dog after consulting with a veterinarian, although proper use of the supplement has not shown any type of adverse side effects in dogs except for mild allergic reactions in dogs that are extremely sensitive to avocado.

Dasuquin can also be obtained without the MSM additive, which is an option you should strongly consider until stronger evidence for both the efficacy and safety of MSM is presented.

Your dog’s weight is an important factor to consider when you are seeking treatment for arthritis, because an overweight dog is at more of a risk for osteoarthritis due to constant strain on the joints. Discussing a weight loss diet with your veterinarian is likely to be helpful.

Special dosage requirements must be followed: one soft chew for dogs under 30 pounds, and two soft chews for dogs over 30 pounds. After the initial four-to-six week period, doses are decreased.

Supplementing healthy dogs

It is important to note that that there is absolutely no scientific data to support this supplement’s function as a preventive measure, and thus it should only be given to dogs that show signs of unhealthy joints.

Side effects of Nutramax Dasuquin

The ingredients in Nutramax Dasuquin for dogs (without MSM) have been shown to be completely safe when given as directed.

As with any medication or supplement, it is important to discuss treatment with your veterinarian and follow the appropriate instructions. Laboratory and clinical studies suggest that the ingredients in Dasuquin are safe, non-toxic, and have a strong likelihood of helping your dog to cope with arthritis. Treatment with this supplement may be helpful both in alleviation of pain and restoration of freedom of motion for dogs with arthritis symptoms.

Osteoarthritis in dogs

Canine osteoarthritis (OA), or degenerative joint disease, may occur as your dog ages, and is exacerbated for overweight dogs. OA has been said to be the primary reason of pain, discomfort, and decreased mobility in aging dogs. This includes a variety of mechanical disorders in joints – including cartilage and bone – and often results in pain and inflammation accompanied by swelling.

Cartilage is the padding in the body that prevents bone from rubbing against other bones in the joint. When cartilage is damaged or worn away, it will create immobility and pain for the dog. Your pet’s discomfort is likely to be obvious, and they will be significantly less willing to walk, run, and jump.

Canine arthritis was once considered a simple consequence of aging, but now there are a variety of treatments to alleviate the pain. Such treatments include not only medications for pain relief, but also supplements and nutraceuticals such as Dasuquin which have been proven to provide symptom relief and at the very least partially restore your dog’s mobility. As outlined below, there is some evidence that the ingredients contained in Dasuquin may help to partially reverse some of dog’s cartilage damage and hopefully reduce pain for arthritic dogs.

Glucosamine hydrochloride and chondroitin sulfate are today’s most popular oral supplements that are presently the subject of considerable scientific investigation with the purpose to finally conclude their effectiveness [1, 2]. Currently, majority of scientific research investigates glucosamine alone [3, and references therein]; however, this supplement is most often given together with chondroitin, both to pets and humans.

Recent large clinical studies on humans have clearly demonstrated that the combination of glucosamine and chondroitin provided “meaningful and sustained analgesia in knee osteoarthritis” [4]. Meta-analyses of currently available research data on both humans and dogs with osteoarthritis strongly indicate a positive effect of treatment with glucosamine and chondroitin [5, 6].

Scientific evidence indicates that the mechanism by which a combination of glucosamine and chondroitin treatment may work is via stimulation of new cartilage matrix production [7, 8]. The combined use of glucosamine and chondroitin has been shown to be synergistic [9, 10].

In addition, Nutramax Dasuquin also contains ASU (oily or fat-like compounds that will not saponify). Manufacturer of the supplement claims that ASU works to support and enhance the effects of glucosamine and chondroitin; however, meta-analysis of ASU do not suggest any significant effect in controlled studies so far [11]. The same meta-analysis also found no positive effect for the use of MSM (methylsulfonylmethane), an optional Dasuqin ingredient [11].

A laboratory study on the use of MSM with a specific rat model for OA found “appropriate intake of MSM is possibly effective,” but – of particular concern – atrophy (shrinkage) of several internal organs was observed [12].

In human trials, use of MSM had no clinical effect on the osteoarthritis disease, but did result in a decrease in patients’ need for anti-inflammatory drugs [13]. Other studies show patients reporting “improvement in pain and physical function” – results that were not of definite clinical significance [14]. When testing with overweight participants, a weight loss program combined with glucosamine, chondroitin and MSM supplementation revealed some improvement in osteoartritic symptoms [15]. However, the study concluded that the actual loss of weight was the primary factor, and that the supplements (and high protein diet) only provided marginal additive benefits. Lastly, another study in humans found MSM treatment, in combination with glucosamine, to be helpful too [16].

In contrast though, meta-analysis of MSM and DMSO (dimethylsulfoxide) studies found no benefit in pain reduction from these compounds in treatment of osteoarthritis. This systematic review also stated that studies to date were not sufficiently rigorous to make any definitive conclusions on the effectiveness of MSM (and DMSO) [17].

So what does it tell us? At present, it is not possible to make a clear-cut decision about the utility of MSM and ASU for treatment of osteoarthritis in dogs, but the benefit of glucosamine and chondroitin is obvious, even if it’s still not completely clear how the positive effect is being achieved. Also, while most studies did not report toxicity from MSM, the rat study where atrophy of internal organs was observed [12] is a somewhat serious report to raise concern when considering adding this nutraceutical to the Dasuquin formulation, but further research is necessary for definite conclusions.

 

References:

  1. Adebowale A et al. The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs. Biopharm Drug Dispos 2002;23(6):217-225. Biopharm Drug Dispos. 2002 Sep;23(6):217-25. [study]
  2. Tsui, T et al. Understanding the role of scientific evidence in consumer evaluation of natural health products for osteoarthritis an application of the means end chain approach. BMC Complement Altern Med. 2012 Oct 30;12:198. doi: 10.1186/1472-6882-12-198
  3. Abimbola O. Analysis of Glucosamine and Chondroitin Sulfate Content in Marketed Products and the Caco-2 Permeability of Chondroitin Sulfate Raw Materials. [pdf]
  4. Provenza, J. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol. 2014 Aug 3. [Epub ahead of print]
  5. Aragon, C. Systematic review of clinical trials of treatments for osteoarthritis in dogs. J Am Vet Med Assoc. 2007 Feb 15;230(4):514-21. [study]
  6. McCarthy, G et al. Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. Vet J. 2007 Jul;174(1):54-61. Epub 2006 May 2. [study]
  7. Johnson, K et al. Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis. Osteoarthritis Cartilage. 2001 Jan;9(1):14-21. [study]
  8. Cox, M et al. Changes in the chondroitin sulfate-rich region of articular cartilage proteoglycans in experimental osteoarthritis. Biochim Biophys Acta. 1985 Jun 18;840(2):228-34. [study]
  9. Calamia, V et al. A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine. Sci Rep. 2014 Jun 10;4:5069. doi: 10.1038/srep05069
  10. Bottegoni, C et al. Oral chondroprotection with nutraceuticals made of chondroitin sulphate plus glucosamine sulphate in osteoarthritis. Carbohydr Polym. 2014 Aug 30;109:126-38. doi: 10.1016/j.carbpol.2014.03.033
  11. Gallagher, B et al. Chondroprotection and the Prevention of Osteoarthritis Progression of the Knee: A Systematic Review of Treatment Agents. Am J Sports Med. 2014 May 27. pii: 0363546514533777. [Epub ahead of print]
  12. Ezaki, J et al. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J Bone Miner Metab. 2013 Jan;31(1):16-25. doi: 10.1007/s00774-012-0378-9
  13. Notarnicola, A et al. The “MESACA” study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv Ther. 2011 Oct;28(10):894-906. doi: 10.1007/s12325-011-0068-3
  14. Debbi, E et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011 Jun 27;11:50. doi: 10.1186/1472-6882-11-50
  15. Magrans-Courtney T et al. Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program. J Int Soc Sports Nutr. 2011 Jun 20;8(1):8. doi: 10.1186/1550-2783-8-8
  16. Usha, P et al. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63. [study]
  17. Brien, S et al. Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee. Evid Based Complement Alternat Med. 2011;2011:528403. doi: 10.1093/ecam/nep045

Disclaimer: The purported effects of the supplements or ingredients discussed in this article may, or may not, have been subject to rigorous scientific investigation.  This article is an introductory document for educational purposes only which is not intended to be a scientific review either endorsing or refuting the claimed effects of the supplements or ingredients. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The supplement has not been tested or tried by the author(s) of the content/review, and are not endorsed or recommended in any way.