Lyme disease in dogs is very common in the United States. Fortunately, there are ways to deal with it.
Unlike many other canine diseases, Lyme disease is also prevalent among humans, thus making it a hot topic among veterinarians and health professionals alike.
Most pet parents are unaware of the prevention, treatments and causes of Lyme diseases in dogs.
Table of Contents
- 1 What is Lyme Disease?
- 2 Deer Ticks
- 3 Symptoms of Lyme Disease in Dogs
- 4 How is Canine Lyme Disease Treated?
- 5 How to Prevent Lyme Disease in Dogs?
- 6 Take Home Message
Diagnosis of Lyme disease is still a tricky business, and remains a topic of multiple debates .
Studies show that as many as one million people in the US may get Lyme disease every year .
There’s no accurate number for canine Lyme disease. However, experts calculate that the increase among the human population applies to dogs, and it’s likely that there are far more cases of dogs contracting Lyme disease than people .
Using scientific evidence, this article aims to introduce owners to dog Lyme disease, and how to effectively prevent and treat it.
What is Lyme Disease?
Lyme disease is one of the top tick-transmitted diseases on the globe . It was first recognized in people in 1975, and in dogs in 1985.
Lyme disease is typically spread by the deer ticks, which are very small arachnids, biting animals without being detected.
The disease is caused by a bacterium called Borrelia burgdorferi which the ticks become infected with by feeding on small animals like mice. When the tick bites another animal, like a dog, they spread the bacteria to them.
Sources of Lyme disease
Most experts agree that only a small portion of the country is endemic for Lyme disease, however. This can be due to a high concentration of people with pets in those areas .
How is Lyme disease transmitted?
Nymphs and adult female deer ticks are the ones who transmit the disease.
In fact, research suggests that out of all dogs exposed to B. burgdorferi, only 10% contract Lyme disease [19, 20].
After the tick has had its meal, it detaches and has no need for biting anybody else.
Can it be transmitted to people?
Lyme disease is considered a zoonotic disease, but there is no evidence that people can contract it from pets .
Although highly unlikely, detached ticks who for some reason didn’t feed themselves on the dog can crawl on humans and infect people that way .
However, studies show that there’s no increased risk of Lyme disease among people owning dogs .
Bottom Line: Lyme disease is transmitted through deer ticks. Dogs in certain parts of the country are at a higher risk. Lyme disease cannot be transmitted from pets to people.
Deer ticks are responsible for transmitting Lyme disease in dogs .
Their official scientific name is Ixodes scapularis, and they’re also known as Blacklegged ticks or Bear ticks.
Deer ticks are one of the most common in the US, alongside American dog tick (Dermacentor variabilis), Lone star tick (Amblyomma americanum) and Groundhog tick (Ixodes cookei) .
These ticks are smaller than the well-known American dog ticks.
Life cycle of ticks
Deer ticks live 2-3 years, and there are several stages/life cycles that deer ticks go through .
The cycle begins when the female tick lays eggs. In spring, the eggs mature and develop into larvae, and start feeding on small mammals like mouse.
The larvae becomes infected with B. burgdorferi and turns into a nymph the following spring. At this point, nymphs start feeding either on same small animals or sometimes bigger mammals.
After this, the tick enters its last stage and becomes an adult tick. Adult deer ticks mostly feed on larger mammals like deer, humans and dogs. It then lays eggs that hatch the following spring.
For the whole process to work, the tick(s) has to remain consistently infected. Breaking the life cycle using certain methods (mentioned below) means the tick will become “ineffective.”
How to remove ticks from a dog?
Dog owners who are confident about removing ticks from their dogs don’t need to go to the vet as long as you remove it before 24 hours have passed.
Removing a tick from the dog isn’t complicated, but you need to be careful.
How to remove a tick:
- Using tweezers, grasp the tick as close to the surface as possible
- Do not jerk or twist the tick, keep it very steady
- Confidently pull the tick upwards
- Ensure that no tick’s mouth parts are left on the skin
- Clean the area and hands with alcohol and/or soap
- Dispose of the tick by placing it in alcohol (don’t crush it)
Do not use any alternative medicine methods. Simply pulling the tick out will work just fine.
If the dog begins to develop fever or other unusual symptoms after the tick has been pulled, see the vet immediately.
Dogs do not develop rashes like people do, so make sure you observe your pet for a while.
Bottom Line: Deer ticks live 2-3 years and have very specific life cycles. Breaking the cycle will “disinfect” the tick.
Symptoms of Lyme Disease in Dogs
The time between infection and the appearance of any symptoms of Lyme disease in dogs is usually 2 to 5 months.
In fact, up to 90 percent of dogs that are affected don’t show any symptoms at all [19, 20].
Lyme disease symptoms can be brief or recurring for dogs. These can include:
- Decreased appetite
- Painful or swollen joints
- Lameness, which may get worse over time or shift from one leg to another.
- Swollen lymph nodes
- Neurological disease (rarely seen in dogs, but it is possible)
- Polydypsia (increased water consumption)
- Kidney disease symptoms (vomiting, loss of appetite, depression, high thirst, change in urination rates)
Complications with kidney functions, heart problems or central nervous system issues are very rare among canines, but this does occur.
How is Lyme disease diagnosed?
Lyme disease in dogs is normally diagnosed through blood tests at the clinic .
Some dogs will test positive for Lyme disease but they don’t necessarily have it. What this means is that they most likely have been exposed to the infection, but their antibodies have fought and won the battle.
Only 10% of dogs exposed to the infection actually contract Lyme disease [19, 20].
Because of this, blood test results will be compared with other methods and information about the dog to draw a more accurate conclusion [29, 30].
Bottom Line: Lyme disease symptoms vary greatly; serious complications are rare. Only 10% of dogs contract Lyme disease, of those infected about 90% do not show any symptoms at all.
How is Canine Lyme Disease Treated?
When a dog has been bitten by a tick, you should diligently watch the dog for signs of Lyme disease.
At the first sign of illness, take them to a veterinarian. Even though the treatment is pretty straightforward, Lyme disease is very persistent.
The two most common antibiotic Lyme disease treatments are doxycycline or amoxicillin, and studies show that both are effective to fight the infection [18, 34].
These antibiotics are given to the dog for 14-30 days straight, but there are no guarantees.
Research shows that even a 30-day treatment does not always completely get rid of the bacteria, and relapses occur . Post-Lyme disease syndrome is also possible where antibiotics stop working .
In certain cases, the treatment can produce a state where the bacteria remains in the dog, but there are no symptoms .
For this reason, it is still a good idea to have your dog’s urine tested for excess protein – a sign of kidney disease – on a regular basis after they have been treated for Lyme disease.
Bottom Line: Antibiotics is the standard treatment of Lyme disease in dogs. Studies show it to be very effective. Total removal of the bacteria isn’t always possible, but the state of “no symptoms” is usually achieved.
How to Prevent Lyme Disease in Dogs?
As a dog owner, you should always be mindful and check your dog for ticks, especially after they have been in the woods or areas with tall grass.
Dogs who have been previously infected can be re-infected.
Checking your dog for ticks on a daily basis is the owner’s best tool against not only Lyme disease in dogs, but also many other infections that ticks can transmit to canines.
Avoiding areas that are known to be infested with ticks is a great way to prevent tick bites.
Ticks can be carried into yards or parks by other animals. Tick season is spring through early fall.
Ticks have to feed for at least 24-48 hours before they are able to transmit the bacteria that cause Lyme disease in dogs, so if you are checking your pet after times of risked exposure, you’ll likely find the ticks in time.
Vaccinations for Lyme disease are available, and are highly effective [40-43, 46-52].
Be sure to do your research and talk to your vet prior to making any such decisions.
Two types of vaccines for Lyme disease in dogs exist that attack the bacteria and prevent transmission.
Vaccines are introduced through giving them twice at 2 to 3 week intervals. After that, annual vaccination is needed to maintain immunity.
Lyme disease vaccinations are a controversial topic because so few dogs actually develop symptoms and it is usually treated very easily.
Since vaccine’s effectiveness depends a lot on dogs themselves and their immune system, vaccination doesn’t guarantee 100% protection against Lyme disease in dogs. Many vaccinated dogs still contract the disease .
Some better known vaccines are:
- Galaxy Lyme (Schering-Plough)
- Recombitek Lyme (Merial)
- ProLyme (Intervet)
- Continuum Lyme (Intervet)
- Lymevax (Fort Dodge)
Most vaccines should be relatively safe but some adverse effects associated with over-vaccination are possible .
In human trials, certain Lyme disease vaccines have shown side effects and were even pulled from the market .
Generally, vets agree that only dogs in endemic areas should be vaccinated.
Tick fighting products
You can also use over the counter products that help prevent parasites, such as insecticides.
Many flea control products include tick protection. Take a look at our article for evidence on which products work and which do not.
Most anti-tick and -flea products offer a topical solution that you apply to your dog just once a month.
However, you must always check your dog for ticks on a daily basis during tick season.
Treating the environment (yard and/or kennel) is also a key step in the prevention of Lyme disease in dogs.
Other environment control methods can help, such as keeping your lawn short and removing vegetation in your backyard.
Ensuring there are no small rodents in your backyard can also help since ticks less sources to feed on.
Bottom Line: Preventing tick bites is the best way to avoid Lyme disease. Tick control is the most effective method. Vaccinations are available and also work. Using flea and tick products is common, and so is controlling the environment.
Take Home Message
Lyme disease in dogs is common, with more dogs contracting it than humans.
The disease is transmitted through bites of deer ticks. Removing a tick before up to 24 hours after the attachment will most likely prevent dogs from being infected.
Lyme disease cannot be transmitted from pets to people, and studies show no evidence of increased cases of Lyme disease among pet owners.
Treatment of canine Lyme disease is effective and straightforward using antibiotics.
Preventing Lyme disease through tick and environment control is best. Vaccines are available; it’s an effective but controversial method.
Over the counter products such as collars, medicine and topical products also work.
- H. A. T. Goossens, A. E. van den Bogaard, M. K. E. Nohlmans. Dogs as Sentinels for Human Lyme Borreliosis in The Netherlands. J Clin Microbiol. 2001 Mar; 39(3): 844–848. doi: 10.1128/JCM.39.3.844-848.2001
- Elizabeth G. Stone, Eleanor H. Lacombe, Peter W. Rand. Antibody Testing and Lyme Disease Risk. Emerg Infect Dis. 2005 May; 11(5): 722–724. doi: 10.3201/eid1105.040381
- J M Lindenmayer, D Marshall, A B Onderdonk. Dogs as sentinels for Lyme disease in Massachusetts. Am J Public Health. 1991 November; 81(11): 1448–1455.
- Peggy Coulter, Clara Lema, Diane Flayhart, Amy S. Linhardt, John N. Aucott, Paul G. Auwaerter, J. Stephen Dumler. Two-Year Evaluation of Borrelia burgdorferi Culture and Supplemental Tests for Definitive Diagnosis of Lyme Disease. J Clin Microbiol. 2005 Oct; 43(10): 5080–5084. doi: 10.1128/JCM.43.10.5080-5084.2005
- Raphael B. Stricker, Lorraine Johnson. Lyme Disease: Call for a “Manhattan Project” to Combat the Epidemic. PLoS Pathog. 2014 Jan; 10(1): e1003796. Published online 2014 Jan 2. doi: 10.1371/journal.ppat.1003796
- Levy SA. Use of a C6 ELISA test to evaluate the efficacy of a whole-cell bacterin for the prevention of naturally transmitted canine Borrelia burgdorferi infection. Vet Ther. 2002 Winter;3(4):420-4.
- Christina Frank, Alan D. Fix, César A. Peña, G. Thomas Strickland. Mapping Lyme Disease Incidence for Diagnostic and Preventive Decisions, Maryland. Emerg Infect Dis. 2002 Apr; 8(4): 427–429. doi: 10.3201/eid0804.000413
- J. Stone Doggett, Sue Kohlhepp, Robert Gresbrink, Paul Metz, Curt Gleaves, David Gilbert. Lyme Disease in Oregon. J Clin Microbiol. 2008 Jun; 46(6): 2115–2118. Published online 2008 Apr 30. doi: 10.1128/JCM.00394-08
- Alpert B1, Esin J, Sivak SL, Wormser GP. Incidence and prevalence of Lyme disease in a suburban Westchester County community. N Y State J Med. 1992 Jan;92(1):5-8.
- C. H. Lawrence, R. Botchlet, S. L. Silberg, D. J. Flournoy, P. J. Guthrie. Prevalence of Lyme disease infection in Oklahoma. J Natl Med Assoc. 1992 Sep; 84(9): 803–804.
- J Piacentino, B Schwartz. Occupational risk of Lyme disease: an epidemiological review. Occup Environ Med. 2002 Feb; 59(2): 75–84. doi: 10.1136/oem.59.2.75
- Paul Mead, Rohan Goel, Kiersten Kugeler. Canine Serology as Adjunct to Human Lyme Disease Surveillance. Emerg Infect Dis. 2011 Sep; 17(9): 1710–1712. doi: 10.3201/1709.110210
- Mead PS. Epidemiology of Lyme disease. Infect Dis Clin North Am. 2015 Jun;29(2):187-210. doi: 10.1016/j.idc.2015.02.010.
- Nicholas H. Ogden, DPhil, L. Robbin Lindsay, PhD, Muhammad Morshed, PhD, Paul N. Sockett, PhD, Harvey Artsob, PhD. The emergence of Lyme disease in Canada. CMAJ. 2009 Jun 9; 180(12): 1221–1222. doi: 10.1503/cmaj.080148
- Franke J1, Hildebrandt A, Meier F, Straube E, Dorn W. Prevalence of Lyme disease agents and several emerging pathogens in questing ticks from the German Baltic coast. J Med Entomol. 2011 Mar;48(2):441-4.
- Firneisz GD, Cochrane SM, Parent J, Houston DM. Ontario. Canine ehrlichiosis in Ontario. Can Vet J. 1990 Sep;31(9):652-3.
- Michael J Cook. Lyme borreliosis: a review of data on transmission time after tick attachment. Int J Gen Med. 2015; 8: 1–8. Published online 2014 Dec 19. doi: 10.2147/IJGM.S73791
- Lo Re V 3rd1, Occi JL, MacGregor RR. Identifying the vector of Lyme disease. Am Fam Physician. 2004 Apr 15;69(8):1935-7.
- Stafford III, Kirby C. 2007. Tick Management Handbook: An Integrated Guide for Homeowners, Pest Control Operators, and Public Health Officials for the Prevention of Tick-Associated Disease. 78 pp.
- Greene, C. Infectious Diseases of the Dog and Cat. W.B. Saunders Co. Philadelphia, PA; 1998.
- Mather TN1, Fish D, Coughlin RT. Competence of dogs as reservoirs for Lyme disease spirochetes (Borrelia burgdorferi). J Am Vet Med Assoc. 1994 Jul 15;205(2):186-8.
- Zenda L. Berrada, Sam R. Telford, III. Burden of tick-borne infections on American companion animals. Top Companion Anim Med. Author manuscript; available in PMC 2010 Nov 1. Published in final edited form as: Top Companion Anim Med. 2009 Nov; 24(4): 175–181. doi: 10.1053/j.tcam.2009.06.005
- Institute of Medicine (US) Committee on Lyme Disease and Other Tick-Borne Diseases: The State of the Science. Critical Needs and Gaps in Understanding Prevention, Amelioration, and Resolution of Lyme and Other Tick-Borne Diseases: The Short-Term and Long-Term Outcomes: Workshop Report. Washington (DC): National Academies Press (US); 2011.
- Barton TR1, Harris MP, Wanless S, Elston DA. The activity periods and life-cycle of the tick Ixodes uriae (Acari: Ixodidae) in relation to host breeding strategies. Parasitology. 1996 Jun;112 ( Pt 6):571-80.
- Summers BA1, Straubinger AF, Jacobson RH, Chang YF, Appel MJ, Straubinger RK. Histopathological studies of experimental lyme disease in the dog. J Comp Pathol. 2005 Jul;133(1):1-13.
- Little SE1, Heise SR, Blagburn BL, Callister SM, Mead PS. Lyme borreliosis in dogs and humans in the USA. Trends Parasitol. 2010 Apr;26(4):213-8. doi: 10.1016/j.pt.2010.01.006. Epub 2010 Mar 6.
- Steven M. Callister, Dean A. Jobe, Ronald F. Schell, Steven D. Lovrich, Keysha L. Onheiber, Jon B. Korshus. Detection of Borreliacidal Antibodies in Dogs after Challenge with Borrelia burgdorferi-Infected Ixodes scapularis Ticks. J Clin Microbiol. 2000 Oct; 38(10): 3670–3674.
- Azuma Y1, Kawamura K, Isogai H, Isogai E. Neurologic abnormalities in two dogs suspected Lyme disease. Microbiol Immunol. 1993;37(4):325-9.
- Jacobson RH1, Chang YF, Shin SJ. Lyme disease: laboratory diagnosis of infected and vaccinated symptomatic dogs. Semin Vet Med Surg (Small Anim). 1996 Aug;11(3):172-82.
- Krupka I1, Straubinger RK. Lyme borreliosis in dogs and cats: background, diagnosis, treatment and prevention of infections with Borrelia burgdorferi sensu stricto. Vet Clin North Am Small Anim Pract. 2010 Nov;40(6):1103-19. doi: 10.1016/j.cvsm.2010.07.011.
- Straubinger RK1, Straubinger AF, Summers BA, Jacobson RH, Erb HN. Clinical manifestations, pathogenesis, and effect of antibiotic treatment on Lyme borreliosis in dogs. Wien Klin Wochenschr. 1998 Dec 23;110(24):874-81.
- Gary P. Wormser1, Ira Schwartz. Antibiotic Treatment of Animals Infected with Borrelia burgdorferi. Clin Microbiol Rev. 2009 Jul; 22(3): 387–395. doi: 10.1128/CMR.00004-09
- Straubinger RK1, Straubinger AF, Summers BA, Jacobson RH. Status of Borrelia burgdorferi infection after antibiotic treatment and the effects of corticosteroids: An experimental study. J Infect Dis. 2000 Mar;181(3):1069-81.
- Bettina Wagner, John Johnson, David Garcia-Tapia, Nicole Honsberger, Vickie King, Catherine Strietzel, John M. Hardham, Thomas J. Heinz, Richard T. Marconi, Patrick F. M. Meeus. Comparison of effectiveness of cefovecin, doxycycline, and amoxicillin for the treatment of experimentally induced early Lyme borreliosis in dogs. BMC Vet Res. 2015; 11: 163. Published online 2015 Jul 25. doi: 10.1186/s12917-015-0475-9
- Straubinger RK1, Summers BA, Chang YF, Appel MJ. Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment. J Clin Microbiol. 1997 Jan;35(1):111-6.
- Adriana Marques. Chronic Lyme Disease: An appraisal. Infect Dis Clin North Am. Author manuscript; available in PMC 2009 Jun 1. Published in final edited form as: Infect Dis Clin North Am. 2008 Jun; 22(2): 341–360. doi: 10.1016/j.idc.2007.12.011
- Anthony T. Gary, Jinelle A. Webb, Barbara C. Hegarty, Edward B. Breitschwerdt. The low seroprevalence of tick-transmitted agents of disease in dogs from southern Ontario and Quebec. Can Vet J. 2006 Dec; 47(12): 1194–1200.
- Roger P. Clark, D.O., Linden T. Hu. Prevention of Lyme Disease (and other tick borne infections). Infect Dis Clin North Am. Author manuscript; available in PMC 2011 Oct 17. Published in final edited form as: Infect Dis Clin North Am. 2008 Sep; 22(3): 381–vii. doi: 10.1016/j.idc.2008.03.007
- K R Wiebe. Canine Lyme borreliosis in Ontario–a case report. Can Vet J. 1995 Aug; 36(8): 513–514.
- Monica E. Embers1, Sukanya Narasimhan. Vaccination against Lyme disease: past, present, and future. Front Cell Infect Microbiol. 2013; 3: 6. Published online 2013 Feb 12. doi: 10.3389/fcimb.2013.00006
- Rhonda L. LaFleur, Steven M. Callister, Jennifer C. Dant, Dean A. Jobe, Steven D. Lovrich, Thomas F. Warner, Terri L. Wasmoen, Ronald F. Schell. One-Year Duration of Immunity Induced by Vaccination with a Canine Lyme Disease Bacterin. Clin Vaccine Immunol. 2010 May; 17(5): 870–874. Published online 2010 Mar 17. doi: 10.1128/CVI.00524-09
- Straubinger RK1, Dharma Rao T, Davidson E, Summers BA, Jacobson RH, Frey AB. Protection against tick-transmitted Lyme disease in dogs vaccinated with a multiantigenic vaccine. Vaccine. 2001 Oct 12;20(1-2):181-93.
- Poland GA. Prevention of Lyme disease: a review of the evidence. Mayo Clin Proc. 2001 Jul;76(7):713-24.
- Chomel B. Lyme disease. Rev Sci Tech. 2015 Aug;34(2):569-76.
- Littman MP. Canine borreliosis. Vet Clin North Am Small Anim Pract. 2003 Jul;33(4):827-62.
- Coughlin RT1, Fish D, Mather TN, Ma J, Pavia C, Bulger P. Protection of dogs from Lyme disease with a vaccine containing outer surface protein (Osp) A, OspB, and the saponin adjuvant QS21. J Infect Dis. 1995 Apr;171(4):1049-52.
- Thomas P. O’Connor, Kathy J. Esty, Jancy L. Hanscom, Paulette Shields, Mario T. Philipp. Dogs Vaccinated with Common Lyme Disease Vaccines Do Not Respond to IR6, the Conserved Immunodominant Region of the VlsE Surface Protein of Borrelia burgdorferi. Clin Diagn Lab Immunol. 2004 May; 11(3): 458–462. doi: 10.1128/CDLI.11.3.458-462.2004
- O’Connor TP1, Esty KJ, Hanscom JL, Shields P, Philipp MT. Dogs vaccinated with common Lyme disease vaccines do not respond to IR6, the conserved immunodominant region of the VlsE surface protein of Borrelia burgdorferi. Clin Diagn Lab Immunol. 2004 May;11(3):458-62.
- Conlon JA1, Mather TN, Tanner P, Gallo G, Jacobson RH. Efficacy of a nonadjuvanted, outer surface protein A, recombinant vaccine in dogs after challenge by ticks naturally infected with Borrelia burgdorferi. Vet Ther. 2000 Spring;1(2):96-107.
- Andrew K Eschner, Kristen Mugnai. Immunization with a recombinant subunit OspA vaccine markedly impacts the rate of newly acquired Borrelia burgdorferi infections in client-owned dogs living in a coastal community in Maine, USA. Parasit Vectors. 2015; 8: 92. Published online 2015 Feb 10. doi: 10.1186/s13071-015-0676-x
- Christina M. Small, Dharani K. Ajithdoss, Aline Rodrigues Hoffmann, Waithaka Mwangi, Maria D. Esteve-Gassent. Immunization with a Borrelia burgdorferi BB0172-Derived Peptide Protects Mice against Lyme Disease. PLoS One. 2014; 9(2): e88245. Published online 2014 Feb 5. doi: 10.1371/journal.pone.0088245
- Van Hoecke C, Comberbach M, De Grave D, Desmons P, Fu D, Hauser P, Lebacq E, Lobet Y, Voet P. Evaluation of the safety, reactogenicity and immunogenicity of three recombinant outer surface protein (OspA) lyme vaccines in healthy adults. Vaccine. 1996 Dec;14(17-18):1620-6.
- Littman MP1, Goldstein RE, Labato MA, Lappin MR, Moore GE. ACVIM small animal consensus statement on Lyme disease in dogs: diagnosis, treatment, and prevention. J Vet Intern Med. 2006 Mar-Apr;20(2):422-34.
- Peter W. Rand, Eleanor H. Lacombe, Susan P. Elias, Bruce K. Cahill, Charles B. Lubelczyk, Robert P. Smith, Jr. Multitarget Test for Emerging Lyme Disease and Anaplasmosis in a Serosurvey of Dogs, Maine, USA. Emerg Infect Dis. 2011 May; 17(5): 899–902. doi: 10.3201/eid1705.100408
- Carmichael LE. Canine viral vaccines at a turning point–a personal perspective. Adv Vet Med. 1999;41:289-307.
- Levy SA1, Lissman BA, Ficke CM. Performance of a Borrelia burgdorferi bacterin in borreliosis-endemic areas. J Am Vet Med Assoc. 1993 Jun 1;202(11):1834-8.
- Scott A Halperin. Lyme disease vaccine. Can J Infect Dis. 2000 May-Jun; 11(3): 132–134.
- Ma J1, Hine PM, Clough ER, Fish D, Coughlin RT, Beltz GA, Shew MG. Safety, efficacy, and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine. Vaccine. 1996 Oct;14(14):1366-74.
- L. E. Nigrovic, K. M. Thompson. The Lyme vaccine: a cautionary tale. Epidemiol Infect. 2007 Jan; 135(1): 1–8. Published online 2006 Aug 8. doi: 10.1017/S0950268806007096
- Vyjayanthi N1, Subramanyam MV. Effect of fenvalerate-20EC on sericigenous insects. I. Food utilization in the late-age larva of the silkworm, Bombyx mori L. Ecotoxicol Environ Saf. 2002 Oct;53(2):206-11.
- Bhattacharya M1, Kaviraj A. Toxicity of the pyrethroid pesticide fenvalerate to freshwater catfish Clarias gariepinus: lethality, biochemical effects and role of dietary ascorbic acid. J Environ Sci Health B. 2009 Aug;44(6):578-83. doi: 10.1080/03601230903000602.
- Adelsbach TL1, Tjeerdema RS. Chemistry and fate of fenvalerate and esfenvalerate. Rev Environ Contam Toxicol. 2003;176:137-54.