Dog supplement description: “K9 Immunity is 100% All-American with no imported ingredients. Aloha Medicinals is the actual manufacturers of this cutting edge immune product for dogs, from start to finish. It is Made with Organic Immune Assist Micron, FDA certified Good Manufacturing Practice (cGMP) produced in an FDA registered facility under Nevada Department of Health Food Manufacturing license.”
[tabs][tab title =”Overview”]K9 Immunity is an all-natural supplement that has helped over one million canine cancer patients. Nearly every one of them showed noticeable improvement within days – all by naturally strengthening their immune system.
This proprietary formula activates all 260 different classes of immune cells to help your dog fight cancer in two, critical ways: keeps existing cells healthy as they replicate, and rids damaged cells (like cancer cells) before they can multiply.[/tab]
[tab title =”Ingredients”]Agaricus blazei, Cordyceps sinensis hybrid, Lentinula edodes, Grifola frondosa, Ganoderma lucidum, Coriolus versicolor.[/tab]
[tab title=”Uses”]K9 Immunity Dosage is 1 capsule for each 10 pounds of your dog’s body weight. You may split the dosage up and give half in the morning and half in the evening or you may give them the full dosage all at once.
14 pounds or less – 1 capsule
14-24 pounds – 2 capsules
25-34 pounds – 3 capsules
35-44 pounds – 4 capsules
45-54 pounds – 5 capsules
55-64 pounds – 6 capsules
65-74 pounds – 7 capsules
75-84 pounds – 8 capsules
85-94 pounds – 9 capsules
95-104 pounds – 10 capsules
105-114 pounds – 11 capsules
115+ pounds – 12 capsules[/tab]
[tab title =”Side Effects”]No side effects reported at the time of this writing; please see detailed breakdown below.[/tab]
[tab title =”Manufactured”]Made in the USA.[/tab][/tabs]
K9 Immunity by Aloha for Dogs
K9 Immunity by Aloha for dogs is a supplement made from mushrooms that is designed to boost the immune system of dogs, particularly those with cancer. With a healthier immune system, your dog is more likely to respond well to cancer treatment, have lessened side-effects to cancer treatments, be protected from potential relapse, and have an improved quality of life. Aloha Medicinals, a global leader in organic medicinal mushrooms, also makes K9 Transfer Factor (our review) and K9 Immunity Plus (our review).
A considerable body of scientific evidence demonstrates that supplements containing specific compounds from mushrooms can be a useful adjuvant, or aid, in treatment of cancer. While the supplements do not fight dog’s cancer directly, they stimulate the immune system so that the dog’s own body can better cope with stresses of the disease and of ongoing treatment.
Important: FDA’s letter to Aloha Medicinals with regards to their products of K9 Transfer Factor and K9 Immunity, as well as other products from the manufacturer not yet reviewed on NextGen Dog.
Background of K9 Immunity by Aloha for Dogs
Cancer is a complex process whereby the cellular ‘rules’ have broken down; unfortunately, this can happen in almost any bodily system. Each cancer type, whether canine lymphoma, osteosarcoma, mammary tumors, etc., is likely to have a separate protocol by which your veterinary treats your dog. However, one way in which dog owners can help their pets is to offer immune support.
The immune system is the part of a dog’s physiology that has the task of recognizing what’s right or wrong within the body, and removing damaged or broken cells. One aspect of the immune system is called cell-mediated immunity. This includes well over 250 different classes of immune-supporting cells and a variety of different types of white blood cells, ranging from leukocytes to T-cells (helpers, killers and suppressors), NK cells, macrophages, and many others.
The immune system protects your dog against disease in at least 2 important ways:
- It recognizes foreign pathogens as distinct from normal healthy tissue
- It recognizes damaged or diseased cells
Once these invading pathogens or damaged cells are recognized, they can be destroyed and removed. However, when the immune system is stressed, whether due to illness or veterinary treatments, it doesn’t function as well, and the dog’s body isn’t functioning optimally.
Early recognition of the role of mushrooms as having potential in the battle against cancer occurred in Japan, where a large population of mushroom farmers had a considerably lower incidence of cancers . The evidence from this epidemiological study was so obvious that it led to further investigations of mushrooms and how they may play a part in protection against cancer in humans and animals.
What is K9 Immunity supplement and how it works?
K9 Immunity is a supplement formulated from 6 different medicinal mushrooms: Agaricus blazei or Matsutake; Cordyceps sinensis hybrid; Lentinula edodes or Shitake; Grifola frondosa or Maitake, hen of the woods; Ganoderma lucidum or Reishi, shelf mushrooms; and Coriolus versicolor or turkeytail.
Each of these mushrooms (or their components) has been proven to have an immune-stimulating effect. The 200+ active ingredients purified from the mushrooms are called hetero-polysaccharides, many of which are beta-glucans. Both LMW (small, or low molecular weight) and HMW (large, or high molecular weight) types of beta-glucans are now included in the K9 Immunity supplement. The latter are made available through patented Immune Assist micron technology.
Beta-glucans are believed to play an active role in stimulating the immune system. One way in which beta-glucans function is to play a role in activation of the CR3 (complement receptor-3) protein on immune system cells. When the CR3 cell receptor is triggered by the beta-glucans, it turns on the cell, which in turn enhances the immune response. Furthermore, “turning the key” on one or more immune cells results in the dog’s body producing even more of these activated immune cells, increasing the immune response.
While to date most clinical and laboratory research has been done on humans and non-canine lab animals, the focus on canine research is increasing. There is some speculation that when your dog is fed the mushroom supplement, the large influx of mushroom fungal cells into the small intestine may result in a secondary enhancement of the body’s immune response. Lentinan is one of the anti-tumor polysaccharide beta-glucans that has been isolated, and is the subject to laboratory and clinical trials .
Another PSP (polysaccharide peptide) extracted from the Coriolus versicolor mushroom has recently been shown to function by “decreasing pain, fatigue, loss of appetite, nausea, and vomiting.”  It also helps to lower elevated body temperatures (fever) in rats.
Recent studies are directed towards better understanding of how the various mushroom fractions work to assist the immune system. There is some evidence that specific mushrooms (such as Reishi and Maitake) may actually do more than just assist the immune system, like directly targeting tumors [4, 5, 6]. However, another clinical trial revealed that the anti-tumor effect of Maitake in rodents was not observed in canines .
Extracts from G. lucidum (Reishi) and L. edodes appear to have a direct effect on tumors and/or an enhancing effect on chemotherapy drugs [7, 8]. A recent review of Maitake mushroom fractions  commented that more systematic studies were required.
What dog owners need to know about this supplement
Recommended dosage of K9 Immunity is 1 capsule per 10 lbs/day. The maximum recommended dosage is 12 capsules a day for a dog weighing over 115 lbs. Saturation dosage is 12 capsules; more is not necessary.
The manufacturer also recommends adding their K9 Transfer Factor to assist and enhance bioavailability. See our review for further research into this supplement.
Why should you give this supplement to a healthy dog
The manufacturer states that it is beneficial for healthy dogs. Use of this supplement boosts the immune system and might protect the dog from potential illnesses.
How will it affect a dog’s health
K9 Immunity is fast-acting, and you should observe improvements in your dog’s health in as little as 7-10 days.
Side effects of K9 Immunity
No toxicity has been reported, even with dosages up to 1000 times. Keep in mind that there is some evidence that K9 Immunity may also function to lower blood sugar; this could be an important consideration if your dog is being treated for diabetes and is being treated with insulin.
Overall, there is strong evidence from a variety of laboratory and clinical trials that specific mushroom supplementation has an immune-stimulating response. This increased activity of the immune system has been shown to have a positive effect in cancer treatment, enabling the patient (canine or human) to better resist the onslaught of the cancer, to better tolerate chemotherapy and potential side-effects, and to have a better potential for long-lasting remission.
While the majority of studies to date have been on humans, there appears to be good correlation of these results for canines. The high level of care taken in the preparation of these supplements, using an FDA-certified quality control laboratory, ensures a safe formulation for the dog.
- Wasser, S. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol (2002) 60:258–274b doi: 10.1007/s00253-002-1076-7
- O’Hara, Y. [Fate of lentinan (antitumor polysaccharide) I : – fate of lentinan in mice, rats, and dogs (author’s transl)]. J Toxicol Sci. 1980 Dec;5 Suppl:59-72. [Article in Japanese; study]
- Jedrzejewski, T. et al. Polysaccharide peptide induces a tumor necrosis factor-α-dependent drop of body temperature in rats. J Therm Biol. 2014 Aug;44:1-4. doi: 10.1016/j.jtherbio.2014.06.003
- Jiang, Y et al. Development of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) Polysaccharides Injection Formulation. Int J Med Mushrooms. 2014;16(5):411-9. [study]
- Konno, S et al. Potential growth inhibitory effect of maitake D-fraction on canine cancer cells. Vet Ther. 2004 Winter;5(4):263-71. [study]
- Hernández-Márquez E et al. Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher Basidiomycetes) on transformed cells by human papillomavirus. Int J Med Mushrooms. 2014;16(2):179-87. [study]
- Griessmayr, P et al. Mushroom-derived maitake PET fraction as single agent for the treatment of lymphoma in dogs. 2007 Nov-Dec;21(6):1409-12. [study]
- Ren, M. Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition. J Tradit Chin Med. 2014 Jun;34(3):309-16. [study]
- N Ulbricht, C et al. Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration. J Soc Integr Oncol. 2009 Spring;7(2):66-72. [study]
Disclaimer: The purported effects of the supplements or ingredients discussed in this article may, or may not, have been subject to rigorous scientific investigation. This article is an introductory document for educational purposes only which is not intended to be a scientific review either endorsing or refuting the claimed effects of the supplements or ingredients. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The supplement has not been tested or tried by the author(s) of the content/review, and are not endorsed or recommended in any way.